El mieloma es un cáncer de las células plasmáticas. Se calcula que en se . de trastornos denominados “discrasias de células plasmáticas”. Las células. Meaning of discrasia in the Portuguese dictionary with examples of use. Synonyms for discrasia and discrasia de celulas plasmaticas. 4. discrasia sanguinea. gammapatía monoclonal. paraproteinemias. discrasia de células plasmáticas. electroforesis de proteínas séricas. mieloma múltiple. macroglobulinemia de.
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MIELOMA Y DCPs
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October Pages Light chain deposition disease. Experience in our environment. Experiencia en nuestro medio.
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This item has plasmaticass. Se trataron 3 pacientes, 2 con mieloma. Fallecieron 4 pacientes, 2 discrasiias mieloma. El tiempo de seguimiento hasta el exitus fue de 13 semanas para los pacientes con mieloma y de semanas para el resto. The Light chain deposition disease LCDD is a strange entity characterised by the deposition of only one type of light chain in the renal tubular basement membranes.
It can be associated to a plasma cell dyscrasia, however, it can occur in the absence of any detectable hematological disorder and it is called idiopathic Plasmaticss. The clinical manifestation is renal insufficiency and nephrotic proteinuria, it does not have a clearly fixed treatment and has a severe prognosis. The aim of this work is to analyse the characteristics of the LCDD cases discasias within our environment. Six cases were identified, all of them between andfrom a total amount of renal biopsies performed during this period, 4 women and 2 men, average age of All the biopsies showed tubular basement membranes thickening and kappa chains with a linear distribution within the same.
In one of the cases the affectation was exclusively tubular interstitial with tubular casts. The monitoring time until the death was 13 weeks for the patients with myeloma and weeks plssmaticas the rest.
The LCDD seems to be more frequent than what has been published and it is associated to the myeloma in half of the cases. The aim of this study was to review our experience with this uncommon disease. Clinical and pathological data and patient course were studied based on clinical records and on the information provided by celulaz with whom the patient was in direct contact at the time of study closure. This procedure has been routinely performed at our hospital since Patients with clinical data suggesting involvement of other organs celuulas considered to have extrarenal involvement due to light chain deposition.
Blood electrophoresis detected no monoclonal peaks in any case.
Hypogammaglobulinemia was found in 5 patients In a patient, light chain study in urine showed a selective elevation of the kappa light chain suggesting a monoclonal peak this patient was subsequently diagnosed of myeloma. Bone marrow was studied in 5 patients. LCDD was the first sign of the disease in all 3 patients with myeloma. No evidence of myeloma or other plasma cell dyscrasia was found in 3 patients.
Table I shows the characteristics of renal biopsies. Mean time from diagnosis to start of dialysis was 46 days range, In patients diagnosed of myeloma and idiopathic LCDD, times to start of dialysis were 96 days range, and 7 days range, respectively. The third patient diagnosed of myeloma died 15 days after admission from an infectious complication and did not receive chemotherapy.
Meaning of “discrasia” in the Portuguese dictionary
She died at two years of follow-up. Mean follow-up time was 15 months in myeloma patients 15 days months and 38 months months in idiopathic LCDD. Of the 4 patients who died Renal biopsy therefore plays an essential role in diagnosis of LCDD and its associated dysproteinemia, as evidenced by this and other studies. Renal biopsy is required for diagnosis. Bone marrow study is not always diagnostic, and routine staining with anti-kappa and anti-lambda sera would therefore be required to prevent the disease from being undiagnosed.
This happened with one of our patients, who underwent two bone marrow aspirations with a one month interval.
discrasias de células plasmáticas – English Translation – Word Magic Spanish-English Dictionary
Two of our myeloma patients received VAD cycles, and renal function improvement was achieved in one of them. Mortality was high in our patients. Wider studies would be required to confirm these results. Renal and patient survival was poor. plasjaticas
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