Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M by Ashland – Food, Beverage & Nutrition

Solubility Studies of Isoniazid Extensive solubility studies for isoniazid were not carried out, as isoniazid was reported to be a class I drug according to biopharmaceutical classification system BCS However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming.

The in vitro release profiles were studied as per the specifications enlisted in previous sections and compared with their respective initial release profiles.

The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of the drug.

A total of 44 ternary formulations and 20 binary formulations were prepared. Viscosity of strong and fragile glass-forming liquids investigated by means of principal component analysis. At the same polymer concentration, a polymer of higher viscosity induces greater chain entanglement than a polymer of low viscosity. Oral matrix tablet formulations for concomitant controlled release of anti-tubercular drugs: The release rate from matrix systems remains unaffected by thin spots, pinholes, and other similar defects, which can be a serious problem with reservoir systems 2.


The f 2 factor value was found to be At a slightly larger HPMC size, the hp,c would be further apart, accounting for the drop in viscosity. Ashland hpcm their documentation available in the regions indicated below: Also, the drug has good solubility in the release medium, and hence, the drug present on the i4m might have been released quickly because of the presence of the more pores in the matrix structure.

L4m complex viscosity profiles of the various formulations containing HPMC were successfully classified into three clusters of low, moderate and high viscosity.

Agricultural Research Service scientists are investigating using the plant-derived HPMC as a substitute for gluten in making all-oat and other grain breads.

Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. Swelling of hydroxypropyl methylcellulose tablets. Each formulation was prepared in triplicates for measurements.

Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies

Many pharmaceutical processes such as hot melt extrusion 2 — 5 and spray congealing 6 — 8 and products such as solid dispersions 910suppositories 11 and pessaries utilize polymer melts.

Smaller particles led to a greater viscosity than larger particles. A higher concentration of solids in the polymer melt retarded the flow of the melt, resulting in higher viscosity. Hiremath and Ranendra N.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

Being in the same cluster, all these grades at various concentrations can be used interchangeably when a similar viscosity is required. One of such method is principal component analysis PCA which allows the visualisation of the most important information contained in the data set On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, it is slightly more expensive hpmd produce due to semisynthetic manufacturing processes.


The release mechanism was found to be anomalous non-Fickian diffusion in all the cases. Since there are k4n three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3.

Archived from the original on Interestingly, the viscosity profiles hppmc formulations with high HPMC concentrations generally exhibited a biphasic curve.

The authors express their sincere gratitude to Birla Institute of Technology and Science, Pilani, India for funding the project. The formulated tablets were evaluated for their physical properties and in vitro release characteristics. This page was last edited on 21 Decemberat A special grade of Methocel VLV, developed for coating purposes, was also included in this study. There is a strong relationship that hpmmc between the polymer molecular weight MW and polymer disentanglement concentration C p,dis Eur J Pharm Biopharm.

The n values ranged from 0.

Open in a separate window. The particles in the melt suspension were dispersed and existed as individual, separated particles. Stability Test Hpmmc isoniazid in matrix-embedded tablets in the case of all polymer formulations was found to follow first-order degradation, as the plots of log percent drug content remaining vs.

However, the release was higher in 0. An introduction to rheology.